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Melatonin can exert its effects by acting through specific cellular receptors on the plasma membrane, similar to other hormones, or through receptor-independent mechanisms that involve complex molecular cross talk with other players
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
Epidemiological data further support this connection: patients with inflammatory bowel disease exhibit a 28%30% increased risk of developing PD (Zhu et al., 2019), and Epstein-Barr virus infection has been linked to PD-like symptoms, highlighting the potential role of immune dysregulation in PD pathogenesis (Rajan et al., 2023
